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What is the downside of taking probiotics? The risks and side effects of taking probiotics

10th Feb 2025

Proven to naturally support the digestive system and overall gut health, probiotics are becoming increasingly popular among our health-savvy generation. However, despite boasting a long list of benefits, there are a small handful of negative factors to take into consideration, too. 

The main drawback to taking probiotics is that they can result in some digestive issues such as bloating, gas and diarrhea. These mild discomforts tend to occur when first starting to take probiotics and then gradually subside. However, this does mean that probiotics may not be suitable for those with certain medical conditions or compromised immune systems. In addition, although it is highly unlikely, there may also be a risk of transferring antibiotic resistance genes to other gut bacteria. 

The following list outlines the various downsides to taking probiotics: 

Side effects of taking probiotics 

Gastrointestinal issues: 

The most common side effect when taking probiotics is digestive discomfort. The likes of bloating, diarrhea and gas have all been linked with probiotic consumption. The good news is that these side effects tend to subside on their own over a short period of time, once the digestive system has had time to adjust. 

Immune system concerns: 

Those with compromised immune systems may be at greater risk of developing certain infections borne from the live bacteria and live cultures present in probiotics. 

Allergic reaction risk 

It is possible that some people may experience one or more allergic reactions to probiotics. 

Disruption of gut microbiome: 

Despite having been proven to enhance gut health, when first introducing a new strain of probiotic, the digestive system may experience a level of disruption, ultimately impacting the balance of bacteria in the gut. 

Antibiotic resistance concerns: 

Although highly unlikely, probiotic bacteria could transfer antibiotic resistance genes to other bacteria in the gut. 

Who should consult a doctor before taking probiotics: 

Most people are able effectively to integrate probiotics into their daily routine without the need for medical advice. However, in some cases, seeking an expert opinion is needed.  

Probiotics are packed with gut-boosting goodness, but the following groups of people should consult their GP or health professional before introducing a new strain into their diet: 

  • People with weakened immune systems 

  • Those with complex or serious medical conditions such as inflammatory bowel disease (IBD) or Crohn's disease 

  • Women who are either pregnant or breastfeeding 

  • Infants and young children  

Factors to consider when taking probiotics: 

  • Begin with a low dose: there’s nothing stopping you from increasing your dosage over time, but starting low will enable your body to adjust more effectively, potentially minimizing side effects and discomfort 

  • Speak with your GP or a trained medical professional: even those in perfect health can benefit from a conversation with a healthcare expert about probiotics. A GP will be able to further advise on how best to take probiotics and provide a deeper insight  the positive and negative factors worth taking into consideration  

  • Choose a reputable brand: resist the temptation to go cheap and take your time to really research the options available to you. In particular, focus your attention on quality-tested products that contain verified strains. This additional research could save you from some uncomfortable side effects, as well as boasting optimal health benefits