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Probiotic research is fast transforming our understanding of human health. Probiotics in general are invaluable for maintaining good health. We’re also learning we need certain strains that produce highly specified health benefits.*

One of these strains is Lactobacillus fermentum ME-3. The startling probiotic breakthrough of ME-3 began in 1995. That’s when award-winning microbiologist Marika Mikelsaar, MD, PhD and her team of research scientists isolated the probiotic strain called Lactobacillus fermentum ME-3. This unique strain is able to produce the super antioxidant glutathione. Since then, Dr. Mikelsaar has dedicated herself to researching the numerous benefits of this revolutionary probiotic.*

Glutathione, The "Master Antioxidant"

Every cell in the human body uses glutathione to maintain cellular health. Scientists call it the “Master Antioxidant” and it’s absolutely vital to: 

• (Immune & Vitality) Maintain a healthy immune system*
• (Detox & Liver Health) Promote healthy liver function*

Working as a glutathione-activating agent via three different mechanisms, Reg’Activ is set to impact the future of preventative and restorative health on a cellular level.

The Discovery of ME-3

20 Years of Published Research Support Reg´Activ Products In 1995, award-winning microbiologist Marika Mikelsaar, MD, PhD and her team of research scientists at the University of Tartu, Estonia isolated a unique probiotic strain. That strain, Lactobacillus fermentum ME-3, is able to produce the super antioxidant glutathione. 

Dr. Mikelsaar’s findings were the fruit of a collaboration between the University of Tartu and the University of Linkoping in Sweden. The two research groups looked at the connections between immune health and gut microbiome profiles in Swedish and Estonian children. They selected these groups for comparison because Estonian kids are known to have especially tolerant immune systems. Could there be a probiotic reason for that? 

There was indeed! The researchers successfully found a unique microbial fingerprint in children with the most balanced immune systems. One of the strains isolated from a healthy Estonian child was Lactobacillus fermentum ME-3. Since that initial discovery, Dr. Mikelsaar has dedicated herself to researching the specific effects of this incredible probiotic. 

Meanwhile, Mihkel Zilmer, MD, PhD, head of the Department of Biochemistry at the University of Tartu, conducted extensive research on ME-3. Dr. Zilmer determined that ME-3 exhibits antioxidant properties—through producing glutathione. Ongoing research has explored how ME-3’s glutathione-production supports the immune system, the cardiovascular system, the liver, and other core body systems.* Research on this unique Lactobacillus strain continues today.

Regarding Dr. Ohhira’s Probiotics® and Reg'Activ™ 

EFI, renowned for recognizing and forging new frontiers in the probiotic health arena 15 years ago with the introduction of Dr. Ohhira’s Probiotics®, has once again redefined the genre with the launch of Reg´Activ™, containing the glutathione-boosting probiotic Lactobacillus fermentum ME-3. Like no other supplements before them, Dr. Ohhira’s and Reg´Activ bestow the body with the tools needed to create and maintain a healthy bacterial balance by producing and recycling the human body’s most important antioxidant, glutathione. 

EFI underscores that Dr. Ohhira Probiotics and Reg´Activ are not rival products. On the contrary, they are extremely synergetic but with differing commitments and capabilities. The similarity between these groundbreaking formulations is the decades of science backing their validity and health restorative effects. 

Dr. Ohhira Probiotics is the final amalgamation of probiotics, prebiotics, organic acids, vitamins, minerals, amino acids and other bioactive nutrients created during the fermentation process.Dr. Ohhira’s is the leading product to “remodel the digestive tract.” A properly functioning digestive tract is critical for optimal functioning of the immune system and overall good health.

ME-3 is proven to produce glutathione naturally in the human body. Working as a glutathione-activating agent via three different mechanisms, Reg’Activ is set to impact the future of preventative and restorative health on a cellular level.

Dr. Ohhira’s and Reg’Activ can safely be consumed separately or in combination depending on an individual’s health goals.

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